Description

The accessibility of AlphaMissense predictions, which are available as an Ensembl plugin or as a large file from Zenodo, may be limited for many researchers and clinicians. To potentially ease the access of this valuable tool, we developed this minimalistic web resource available under the "Search" menu. We find this application useful for

  • visually and individually inspecting all variants of a protein,
  • downloading this dataset as a tsv file for local analysis, e.g. using Excel.

In addition, the predicted pathogenicity scores can help to identify mutational hot/cold spots in proteins. To facilitate associated studies we calculated the average pathogenicity score for each residue and made this data available in a table format and also in protein structure context under the "Hotspot" menu. Tables and AlphaFold structures containing the mean scores can be downloaded for local analysis. Under "Download" we also provide

  • All structure files with mean AlphaMissense score per residue in the occupancy and B-factor columns,
  • A PyMOL plugin to color these structures.

If you have some question, feedback, or request: contact us.

Disclaimer: The AlphaMissense Database and other information provided on or linked to this site is for theoretical modelling only, caution should be exercised in use. It is provided "as-is" without any warranty of any kind, whether express or implied. For clarity, no warranty is given that use of the information shall not infringe the rights of any third party (and this disclaimer takes precedence over any contrary provisions in the Google Cloud Platform Terms of Service). The information provided is not intended to be a substitute for professional medical advice, diagnosis, or treatment, and does not constitute medical or other professional advice.

Data contained within the AlphaMissense Database is provided for non-commercial research use only under CC BY-NC-SA 4.0 license.